BDBM19784 (2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}butan-2-yl N-[2-oxo-3-(pyridine-2-sulfonamido)propyl]carbamate::ketone analog, 3a

SMILES CC(C)(C)[C@@H](Cn1ccc(n1)-c1ccc(cc1)C(F)(F)F)OC(=O)NCC(=O)CNS(=O)(=O)c1ccccn1

InChI Key InChIKey=NKGFWSINYBGTKN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 19784   

TargetCathepsin K(Human)
Gsk

LigandPNGBDBM19784((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 65nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed