BDBM19794 (2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-dimethylbutan-2-yl N-[(3S)-2-oxo-1-(pyridine-2-sulfonamido)heptan-3-yl]carbamate::ketone analog, 3k

SMILES CCCC[C@H](NC(=O)O[C@H](Cn1cnc2cc(Cl)c(Cl)cc12)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1

InChI Key InChIKey=CTAIZAPBSQNUAF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 19794   

TargetCathepsin K(Human)
Gsk

LigandPNGBDBM19794((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...)
Affinity DataIC50: 3.20nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Gsk

LigandPNGBDBM19794((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...)
Affinity DataIC50: 10nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Gsk

LigandPNGBDBM19794((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...)
Affinity DataIC50: 16nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin B(Human)
Gsk

LigandPNGBDBM19794((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...)
Affinity DataIC50: 40nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed