BDBM19849 (1S,2S)-N-(cyanomethyl)-5,5-difluoro-2-{2-[4-(methylsulfanyl)phenyl]phenyl}cyclohexane-1-carboxamide::Cyclohexanecarboxamide derivative, (+)-34a

SMILES CSc1ccc(cc1)-c1ccccc1[C@H]1CCC(F)(F)C[C@@H]1C(=O)NCC#N

InChI Key InChIKey=AINATGOAAJKINN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19849   

TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19849((1S,2S)-N-(cyanomethyl)-5,5-difluoro-2-{2-[4-(meth...)
Affinity DataIC50: 7.10nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2008
Entry Details Article
PubMed
TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19849((1S,2S)-N-(cyanomethyl)-5,5-difluoro-2-{2-[4-(meth...)
Affinity DataIC50: 9.20nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2008
Entry Details Article
PubMed