BDBM19853 (1R,2R,5R)-N-(cyanomethyl)-5-fluoro-2-{2-[4-(methylsulfanyl)phenyl]phenyl}cyclohexane-1-carboxamide::Cyclohexanecarboxamide derivative, rac-38b::racemic mixture

SMILES CSc1ccc(cc1)-c1ccccc1[C@@H]1CC[C@@H](F)C[C@H]1C(=O)NCC#N

InChI Key InChIKey=SVGXUGNWPUHTTJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19853   

TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19853(racemic mixture | (1R,2R,5R)-N-(cyanomethyl)-5-flu...)
Affinity DataIC50: 3.70nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2008
Entry Details Article
PubMed
TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19853(racemic mixture | (1R,2R,5R)-N-(cyanomethyl)-5-flu...)
Affinity DataIC50: 12nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2008
Entry Details Article
PubMed