BDBM199157 3,10,11-trimethoxy-5,6,8,9,14,14a-hexahydrobenzo[4,5]azepino[2,1-a]isoquinolin-2-ol (15d)

SMILES COc1cc2CCN3CCc4c(CC3c2cc1O)ccc(OC)c4OC

InChI Key InChIKey=MULALUUHQOTCGR-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 199157   

TargetD(1A) dopamine receptor(Human)
Fudan University

LigandPNGBDBM199157(3,10,11-trimethoxy-5,6,8,9,14,14a-hexahydrobenzo[4...)
Affinity DataKi:  30.3nMAssay Description:The transfection of plasmid and membrane preparations was conducted as described in our previous report, with 0.7 nm [3H] SCH23390 (D1R) or [3H]Spipe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Fudan University

LigandPNGBDBM199157(3,10,11-trimethoxy-5,6,8,9,14,14a-hexahydrobenzo[4...)
Affinity DataKi:  84.0nMAssay Description:The transfection of plasmid and membrane preparations was conducted as described in our previous report, with 0.7 nm [3H] SCH23390 (D1R) or [3H]Spipe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Fudan University

LigandPNGBDBM199157(3,10,11-trimethoxy-5,6,8,9,14,14a-hexahydrobenzo[4...)
Affinity DataKi:  284nMAssay Description:The transfection of plasmid and membrane preparations was conducted as described in our previous report, with 0.7 nm [3H] SCH23390 (D1R) or [3H]Spipe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Fudan University

LigandPNGBDBM199157(3,10,11-trimethoxy-5,6,8,9,14,14a-hexahydrobenzo[4...)
Affinity DataIC50: 3.35E+4nMpH: 7.5Assay Description:The [35S]GTPγS binding assay was performed at 30 °C for 30 min containing 10 μgof membrane protein in a final volume of 100 μL with va...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed