BDBM201597 2,3,5-trimethyl-6-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)ethyl)pyrazine::US9540384, 8

SMILES Cc1nc(C)c(CCc2cccc(n2)N2CCCC2)nc1C

InChI Key InChIKey=GPNNVVHDPANIEG-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 201597   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Hoffmann-La Roche

US Patent

LigandBDBM201597(2,3,5-trimethyl-6-(2-(6-(pyrrolidin-1-yl)pyridin-2...)Copy SMILESCopy InChI

Affinity DataIC50: 600nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/7/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL