BDBM202073 US9233983, A-1::US9233983, B-2

SMILES CN1CCN(Cc2ccc(cc2)-c2cc3c(ncnc3[nH]2)-c2cccc(N3CCOc4cc(ccc4C3=O)C3CC3)c2C)CC1

InChI Key InChIKey=UNPRODJUZQZSMD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 202073   

TargetTyrosine-protein kinase BTK(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM202073(US9233983, B-2 | US9233983, A-1)
Affinity DataIC50: 7nMAssay Description:The inhibition assays were performed using the generic tyrosine kinase assay kit from C is Bio (HTRF KinEASE-TK #62TK0PEB). The assay is based on the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM202073(US9233983, B-2 | US9233983, A-1)
Affinity DataIC50: 31nMAssay Description:The inhibition assays were performed using the generic tyrosine kinase assay kit from C is Bio (HTRF KinEASE-TK #62TK0PEB). The assay is based on the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM202073(US9233983, B-2 | US9233983, A-1)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human full length BTK preincubated for 10 mins followed by Tk-biotin peptide substrate addition after 90 mins by TR-FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed