BDBM202253 5,7-dimethyl-2-[2-(6-pyrrolidin-1-yl-pyridin-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrimidine::Roche-Dataset for PDE10A, Compound 992::US9540384, 48

SMILES Cc1cc(C)n2nc(CCc3cccc(n3)N3CCCC3)nc2n1

InChI Key InChIKey=GWCKPBKMZGOQLR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 202253   

LigandPNGBDBM202253(5,7-dimethyl-2-[2-(6-pyrrolidin-1-yl-pyridin-2-yl)...)
Affinity DataIC50: 110nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202253(5,7-dimethyl-2-[2-(6-pyrrolidin-1-yl-pyridin-2-yl)...)
Affinity DataIC50: 114nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed