BDBM202620 US9242943, 29

SMILES C[C@]1(COCC(N)=N1)c1cc(Nc2cccc3cc(OC(F)F)cnc23)ccc1F

InChI Key InChIKey=CHPYWNCYTLASBD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 202620   

TargetBeta-secretase 1(Human)
Siena Biotech

US Patent
LigandPNGBDBM202620(US9242943, 29)
Affinity DataIC50: 270nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Siena Biotech

US Patent
LigandPNGBDBM202620(US9242943, 29)
Affinity DataIC50: 2.30E+3nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetCathepsin E(Human)
Siena Biotech

US Patent
LigandPNGBDBM202620(US9242943, 29)
Affinity DataIC50: 1.76E+4nMpH: 5.5 T: 2°CAssay Description:A substrate peptide is labeled at the N-terminus with tryptophan and at the C-terminus with the fluorophore MR121 (for cathepsin D the 10 amino acid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetCathepsin D(Human)
Siena Biotech

US Patent
LigandPNGBDBM202620(US9242943, 29)
Affinity DataIC50: 2.11E+4nMpH: 5.5 T: 2°CAssay Description:A substrate peptide is labeled at the N-terminus with tryptophan and at the C-terminus with the fluorophore MR121 (for cathepsin D the 10 amino acid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent