BDBM20878 (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methoxyphenyl)methyl]phenoxy}oxane-3,4,5-triol::CHEMBL270766::O-glucoside, 4a

SMILES COc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1

InChI Key InChIKey=HFLCZNNDZKKXCS-UHFFFAOYSA-N

Data  4 KI  7 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 20878   

TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50:  9.20nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50: >8.00E+3nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50: 6.25nMAssay Description:Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50: >8.00E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50:  9.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSodium/glucose cotransporter 1(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human kidney SGLT2 assessed as renal glucose reabsorptionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human kidney SGLT2 assessed as renal glucose reabsorptionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSodium/glucose cotransporter 1(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataKi:  708nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed