BDBM212970 US9278960, 4-54::US9663506, Example 4-54

SMILES Cn1cc(cn1)-c1cc(nc2cc(CN3CCO[C@H](C3)C(F)(F)F)ccc12)C(N)=O

InChI Key InChIKey=PUIAIYDBFPDZPF-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 212970   

LigandPNGBDBM212970(US9278960, 4-54 | US9663506, Example 4-54)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212970(US9278960, 4-54 | US9663506, Example 4-54)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212970(US9278960, 4-54 | US9663506, Example 4-54)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

LigandPNGBDBM212970(US9278960, 4-54 | US9663506, Example 4-54)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM212970(US9278960, 4-54 | US9663506, Example 4-54)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of NaV 1.5 channel (unknown origin) by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM212970(US9278960, 4-54 | US9663506, Example 4-54)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed