BDBM21825 2-[(1S)-5-{3-[4-(4-ethoxy-5-ethyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl]acetic acid::Indanylacetic Acid Analog, 34an

SMILES CCOc1nc(sc1CC)-c1ccc(OCCCOc2ccc3[C@H](CC(O)=O)CCc3c2)c(OC)c1

InChI Key InChIKey=RJIACDQCZJMWDM-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 21825   

TargetPeroxisome proliferator-activated receptor delta(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21825(2-[(1S)-5-{3-[4-(4-ethoxy-5-ethyl-1,3-thiazol-2-yl...)
Affinity DataEC50:  5.40nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21825(2-[(1S)-5-{3-[4-(4-ethoxy-5-ethyl-1,3-thiazol-2-yl...)
Affinity DataEC50:  362nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21825(2-[(1S)-5-{3-[4-(4-ethoxy-5-ethyl-1,3-thiazol-2-yl...)
Affinity DataEC50:  520nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21825(2-[(1S)-5-{3-[4-(4-ethoxy-5-ethyl-1,3-thiazol-2-yl...)
Affinity DataEC50:  1.92E+6nMAssay Description:Agonist activity at GST-tagged Homo sapiens (human) PPARalpha ligand binding domain after 2 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21825(2-[(1S)-5-{3-[4-(4-ethoxy-5-ethyl-1,3-thiazol-2-yl...)
Affinity DataEC50:  5.62E+6nMAssay Description:Agonist activity at Homo sapiens (human) PPARgamma expressed in mouse 3T3-L1 cells incubated for 2 days followed by compound wash out measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetPeroxisome proliferator-activated receptor delta(Human)
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21825(2-[(1S)-5-{3-[4-(4-ethoxy-5-ethyl-1,3-thiazol-2-yl...)
Affinity DataEC50:  1.85E+8nMAssay Description:Agonist activity at GST-tagged Homo sapiens (human) PPARdelta ligand binding domain after 2 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article