BDBM21895 2,9-disubstituted 6-oxopurine, 12s::9-(4-{4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl}butyl)-2-(phenylamino)-6,9-dihydro-3H-purin-6-one dihydrochloride

SMILES OC1(CCN(CCCCn2cnc3c2nc(Nc2ccccc2)[nH]c3=O)CC1)c1ccc(Cl)c(c1)C(F)(F)F

InChI Key InChIKey=NXTQVMUVBFNMQZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21895   

TargetThymidine kinase(HHV-1)
Glsynthesis

LigandPNGBDBM21895(9-(4-{4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hyd...)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:Recombinant HSV TKs were assayed in reaction mixture containing substrate [3H-methyl]TdR and test compounds. After reaction was stopped, the radioact...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetThymidine kinase(HHV-2)
Glsynthesis

LigandPNGBDBM21895(9-(4-{4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hyd...)
Affinity DataIC50: 200nMAssay Description:Recombinant HSV TKs were assayed in reaction mixture containing substrate [3H-methyl]TdR and test compounds. After reaction was stopped, the radioact...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed