BDBM21969 3-[(4S,6S)-4,9-diamino-6-hydroxynonyl]-1-nitroguanidine::Hydroxyethylene derivative, 8

SMILES NCCC[C@H](O)C[C@@H](N)CCCN=C(N)N[N+]([O-])=O

InChI Key InChIKey=JQJDNJUXEQFXTG-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 21969   

TargetNitric oxide synthase, endothelial(Bovine)
Northwestern University

LigandPNGBDBM21969(3-[(4S,6S)-4,9-diamino-6-hydroxynonyl]-1-nitroguan...)
Affinity DataIC50: 1.40E+6nMpH: 7.4 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Northwestern University

LigandPNGBDBM21969(3-[(4S,6S)-4,9-diamino-6-hydroxynonyl]-1-nitroguan...)
Affinity DataIC50: 3.61E+5nMpH: 7.4 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
Northwestern University

LigandPNGBDBM21969(3-[(4S,6S)-4,9-diamino-6-hydroxynonyl]-1-nitroguan...)
Affinity DataKi:  2.80E+3nM ΔG°:  -7.70kcal/mole IC50: 2.35E+4nMpH: 7.4 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed