BDBM222190 6-(Dimethylamino)-3-(3'-bromo-4'-methoxyphenyl)-2,3-dihydronaphtho[1,8-de][1,2]thiazine 1,1-dioxide (7l)

SMILES COc1ccc(cc1Br)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C

InChI Key InChIKey=ADPYHOYMLSCAFL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 222190   

TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bovine)
Monash University

Curated by ChEMBL
LigandPNGBDBM222190(6-(Dimethylamino)-3-(3'-bromo-4'-methoxyph...)
Affinity DataIC50: 300nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bovine)
Monash University

Curated by ChEMBL
LigandPNGBDBM222190(6-(Dimethylamino)-3-(3'-bromo-4'-methoxyph...)
Affinity DataIC50: 300nMpH: 9.8 T: 2°CAssay Description:Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bovine)
Monash University

Curated by ChEMBL
LigandPNGBDBM222190(6-(Dimethylamino)-3-(3'-bromo-4'-methoxyph...)
Affinity DataIC50: 3.48E+3nMpH: 9.8 T: 2°CAssay Description:Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetIntestinal-type alkaline phosphatase(Bovine)
Monash University

Curated by ChEMBL
LigandPNGBDBM222190(6-(Dimethylamino)-3-(3'-bromo-4'-methoxyph...)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of bovine IAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed