BDBM222538 US9315489, 74

SMILES FC(F)(F)Oc1ccc(NC(=O)c2cncc(c2)-c2cccnc2)cc1

InChI Key InChIKey=VGZOEYFNUDMUIX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 222538   

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Novartis

US Patent
LigandPNGBDBM222538(US9315489, 74)
Affinity DataIC50: 8.70nMpH: 7.5 T: 2°CAssay Description:For determination of ABL kinase activity, the radiometric filter-binding assay was used. The assay was performed by mixing 10 μL of the compound p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM222538(US9315489, 74)
Affinity DataIC50: 33nMAssay Description:Inhibition of transphosphorylation of ABL1 SH1-3 domain (64 to 515 residues) (unknown origin) expressed in Escherichia coli using FITC-Ahx-EAIYAAPFAK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed