BDBM22255 2,4,5-tri-substituted imidazole, 21c::4-(2-chlorophenyl)-N-{2-[5-(4-methoxyphenyl)-2-(thiophen-2-yl)-1H-imidazol-4-yl]ethyl}piperazine-1-sulfonamide

SMILES COc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N1CCN(CC1)c1ccccc1Cl)-c1cccs1

InChI Key InChIKey=VDHKOWSRLQHFMY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22255   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb

LigandPNGBDBM22255(4-(2-chlorophenyl)-N-{2-[5-(4-methoxyphenyl)-2-(th...)
Affinity DataIC50: 45nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2008
Entry Details Article
PubMed