BDBM223268 2-(5-((4-Chlorophenyl)(cyclopropylmethyl)amino)-3-methoxypicolinoyl)-N-((2-fluorophenyl)sulfonyl)-cyclopropanecarboxamide::US20160326143, 43::US9657001, 43

SMILES COc1cc(cnc1C(=O)C1CC1C(=O)NS(=O)(=O)c1ccccc1F)N(CC1CC1)c1ccc(Cl)cc1

InChI Key InChIKey=MRGVLSMIFAMSBA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 223268   

TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandPNGBDBM223268(2-(5-((4-Chlorophenyl)(cyclopropylmethyl)amino)-3-...)
Affinity DataIC50: 74nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details
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TargetLeukotriene C4 synthase(Human)
Astrazeneca

US Patent
LigandPNGBDBM223268(2-(5-((4-Chlorophenyl)(cyclopropylmethyl)amino)-3-...)
Affinity DataIC50: 74nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent