BDBM224023 Dextrorphan

SMILES CN1CC[C@]23CCCC[C@@H]2[C@H]1Cc1ccc(O)cc31

InChI Key

Data  4 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 224023   

TargetMas-related G-protein coupled receptor member X2(Human)
University of North Carolina

LigandPNGBDBM224023(Dextrorphan)
Affinity DataEC50:  3.90E+3nMpH: 7.4 T: 2°CAssay Description:MRGPRX2 stable cells were maintained in DMEM containing 10% FBS, 100 μg/ml hygromycin B, and 15 μg/ml blasticidin. For the calcium mobiliza...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2017
Entry Details Article
PubMed
TargetMas-related G-protein coupled receptor member X2(Human)
University of North Carolina

LigandPNGBDBM224023(Dextrorphan)
Affinity DataEC50:  4.20E+3nMpH: 7.4 T: 2°CAssay Description:HTLA cells (HEK-T cells stably expressing a β-arrestin2-TEV fusion protein and a tTa-dependent luciferase reporter) were maintained in DMEM (Cor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2017
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Gilead Sciences

US Patent
LigandPNGBDBM224023(Dextrorphan)
Affinity DataIC50: 1.77E+4nMAssay Description:Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.25%) are incubated with human liver microsome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM224023(Dextrorphan)
Affinity DataKi:  118nMAssay Description:Displacement of [3H]-Citalopram from sigma-1 receptor (unknown origin) expressed in HEK cell membrane incubated for 2 hrs by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM224023(Dextrorphan)
Affinity DataKi: >340nMAssay Description:Displacement of [3H]-Citalopram from NET (unknown origin) expressed in HEK cell membrane incubated for 2 hrs by liquid scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM224023(Dextrorphan)
Affinity DataKi:  401nMAssay Description:Displacement of [3H]-Citalopram from SERT receptor (unknown origin) expressed in HEK cell membrane incubated for 2 hrs by liquid scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM224023(Dextrorphan)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-Citalopram from sigma-2 receptor (unknown origin) expressed in HEK cell membrane incubated for 2 hrs by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed