BDBM224024 BDBM50241435::Dynorphin A (1-13)::YGGFLRRXRPKLK

SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#8])=O

InChI Key InChIKey=BPRFTAUTMQBGFJ-UHFFFAOYSA-N

Data  21 KI  5 IC50  13 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 224024   

TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of [3H]DPDPE binding to delta opioid receptor of guinea pig brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  18nMAssay Description:Binding affinity towards k-opioid receptor k-EL-2 mutant (wild-type) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  18nMAssay Description:Effective concentration to inhibit wild type KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  6nMAssay Description:Effective concentration to inhibit E203Q,D204N,D206N KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  8nMAssay Description:Effective concentration to inhibit D216,ND217N,E218Q KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human recombinant KOR expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human recombinant DOR expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  214nMAssay Description:Agonist activity at human recombinant MOR expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2017
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at human recombinant KOR expressed in CHO cells assessed as calcium mobilization by Fluo-4 AM based fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human recombinant DOR expressed in CHO cells assessed as calcium mobilization by Fluo-4 AM based fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  214nMAssay Description:Agonist activity at human recombinant MOR expressed in CHO cells assessed as calcium mobilization by Fluo-4 AM based fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  40nMAssay Description:Agonist activity at kappa-opioid receptor (unknown origin) after 90 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2016
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of delta-selective antagonist binding to opioid receptor of mouse vas dferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of mu-selective antagonist binding to opioid receptor of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataIC50: 0.114nMAssay Description:Inhibition of [3H]U-69593 binding to kappa opioid receptor of guinea pig brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of [3H]PL-17 binding to mu opioid receptor of guinea pig brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMas-related G-protein coupled receptor member X2(Human)
University of North Carolina

LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  3.00E+4nMpH: 7.4 T: 2°CAssay Description:HTLA cells (HEK-T cells stably expressing a β-arrestin2-TEV fusion protein and a tTa-dependent luciferase reporter) were maintained in DMEM (Cor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2017
Entry Details Article
PubMed
TargetMas-related G-protein coupled receptor member X2(Human)
University of North Carolina

LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  1.00E+3nMpH: 7.4 T: 2°CAssay Description:MRGPRX2 stable cells were maintained in DMEM containing 10% FBS, 100 μg/ml hygromycin B, and 15 μg/ml blasticidin. For the calcium mobiliza...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2017
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  0.000800nMAssay Description:Binding affinity towards Wild-type kappa opioid receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  0.310nMAssay Description:Binding affinity to Opioid receptor kappa 1 by competitive inhibition of radioligand [3H]diprenorphine using cloned receptors transiently expressed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  0.600nMAssay Description:Binding constant against E203Q,D204N,D206N EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  0.800nMAssay Description:Binding constant against wild type EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  0.920nMAssay Description:Binding affinity to Opioid receptor mu 1 by competitive inhibition of radioligand [3H]DAMGO using cloned receptors transiently expressed on CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  1.10nMAssay Description:Binding constant against E203Q,D204N,D206N,E209Q EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Targetkappa-type opioid receptor isoform 1(Western clawed frog)
Biological Research Center of Hungarian Academy of Sciences

Curated by PDSP Ki Database
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  3.40nMAssay Description:Binding constant against D216N,D217N,E218Q EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  3.60nMAssay Description:The compound was tested for binding activity towards opioid receptor kappa in guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
Targetkappa-type opioid receptor isoform 1(Western clawed frog)
Biological Research Center of Hungarian Academy of Sciences

Curated by PDSP Ki Database
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  14.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  16nMAssay Description:The compound was tested for binding activity towards Opioid receptor delta 1 in guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  16.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  28nMAssay Description:Binding affinity to Opioid receptor delta 1 by competitive inhibition of radioligand [3H]DPDPE using cloned receptors transiently expressed on CHO ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  50nMAssay Description:The compound was tested for binding activity towards opioid receptor mu in guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  57nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataKi:  343nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2012
Entry Details Article
PubMed