BDBM22565 2-arylbenzimidazole lead compound 1::5-chloro-2-{4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-1H-1,3-benzodiazole

SMILES CN1CCN(CCCOc2ccc(cc2)-c2nc3ccc(Cl)cc3[nH]2)CC1

InChI Key InChIKey=XWPRDTKOKZWAJZ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 22565   

TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM22565(5-chloro-2-{4-[3-(4-methylpiperazin-1-yl)propoxy]p...)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM22565(5-chloro-2-{4-[3-(4-methylpiperazin-1-yl)propoxy]p...)
Affinity DataKi:  124nM ΔG°:  -9.42kcal/molepH: 7.5 T: 2°CAssay Description:The Ki values were calculated based on an experimentally determined appropriate Kd value according to Cheng and Prusoff.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2008
Entry Details Article
PubMed