BDBM22611 JMC496646 Compound 16::N-Me-pyrimidone deriv., 11::N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-2-(1-methylpiperidin-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide

SMILES CN1CCCCC1c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C

InChI Key InChIKey=HGPPRMHXEAZMCS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 22611   

TargetGag-Pol polyprotein(HIV-1)
Irbm-Mrl

LigandPNGBDBM22611(JMC496646 Compound 16 | N-[(4-fluorophenyl)methyl]...)
Affinity DataIC50: 210nMpH: 7.8 T: 2°CAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM22611(JMC496646 Compound 16 | N-[(4-fluorophenyl)methyl]...)
Affinity DataIC50: 440nMAssay Description:Inhibition of recombinant HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetGag-Pol polyprotein(HIV-1)
Irbm-Mrl

LigandPNGBDBM22611(JMC496646 Compound 16 | N-[(4-fluorophenyl)methyl]...)
Affinity DataIC50: 440nMpH: 7.8 T: 2°CAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed