BDBM226314 (R)-3-((S)-3-(((R)-8-(5-((1S,3S)-2-(2,2- difluoroethyl)-3-methyl-2,3,4,9-tetrahydro- 1H-pyrido[3,4-b]indol-1-yl)pyrimidin-2- yl)-1-oxa-8-azaspiro[4.5]decan-3- yl)methyl)-8-oxo-1,2,3,4,4a,5,8,10- octahydro-9H- pyrazino[1',2':4,5][1,4]oxazino[2,3- f]isoindol-9-yl)piperidine-2,6-dione::US20260007681, Compound A69

SMILES C[C@H]1Cc2c([nH]c3ccccc23)[C@H](c2cnc(N3CCC4(CC3)C[C@H](CN3CCN5c6cc7c(cc6OC[C@@H]5C3)C(=O)N([C@@H]3CCC(=O)NC3=O)C7)CO4)nc2)N1CC(F)F

InChI Key InChIKey=ZUJQZWBFRDDBCA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 226314   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
University Of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 226314BDBM226314((R)-3-((S)-3-(((R)-8-(5-((1S,3S)-2-(2,2- difluoroe...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
University Of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 226314BDBM226314((R)-3-((S)-3-(((R)-8-(5-((1S,3S)-2-(2,2- difluoroe...)
Affinity DataIC50: 275nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2026
Entry Details
US Patent