BDBM226387 US9328096, 80

SMILES Cc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O

InChI Key InChIKey=KCLUHVZXIYSCNX-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 226387   

TargetHigh affinity nerve growth factor receptor [441-796](Human)
Pfizer

US Patent

LigandBDBM226387(US9328096, 80)Copy SMILESCopy InChI

Affinity DataIC50: 43.0nMT: 2°CAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/15/2017
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetHigh affinity nerve growth factor receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM226387(US9328096, 80)Copy SMILESCopy InChI

Affinity DataIC50: 41nMAssay Description:Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/18/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL