BDBM22643 N-Me-pyrimidone deriv., 42::N-[(4-fluorophenyl)methyl]-5-hydroxy-2-(4-methanesulfonyl-1-methylpiperazin-2-yl)-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide

SMILES CN1CCN(CC1c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C)S(C)(=O)=O

InChI Key InChIKey=MWPWGZXQCAMTQA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 22643   

TargetGag-Pol polyprotein(HIV-1)
Irbm-Mrl

LigandPNGBDBM22643(N-[(4-fluorophenyl)methyl]-5-hydroxy-2-(4-methanes...)
Affinity DataIC50: 11nMAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM22643(N-[(4-fluorophenyl)methyl]-5-hydroxy-2-(4-methanes...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed