BDBM226502 US9328096, 195

SMILES Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1COC1)-c1ccccn1

InChI Key InChIKey=IVYVVPAINZAEEL-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 226502   

TargetHigh affinity nerve growth factor receptor [441-796](Human)
Pfizer

US Patent

LigandBDBM226502(US9328096, 195)Copy SMILESCopy InChI

Affinity DataIC50: 9.90nMT: 2°CAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/15/2017
Entry Details
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TargetHigh affinity nerve growth factor receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM226502(US9328096, 195)Copy SMILESCopy InChI

Affinity DataIC50: 9.90nMAssay Description:Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/18/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL