BDBM22970 2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid::CHEMBL320140::Indomethacin derivative, 23

SMILES COc1ccc2n(Cc3ccc(Br)cc3)c(C)c(CC(O)=O)c2c1

InChI Key InChIKey=VYGRRQURXQHVSD-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 22970   

TargetProstaglandin G/H synthase 1(Sheep)
Vanderbilt University School of Medicine

LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50: 6.60E+4nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Vanderbilt University School of Medicine

LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50: 2.50E+3nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50: 3.80E+3nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Vanderbilt University School of Medicine

LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50: 6.60E+4nMAssay Description:In vitro inhibitory activity against ovine Prostaglandin G/H synthase 1 (44 nM) using [14C]AA (50 uM) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Vanderbilt University School of Medicine

LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50: 2.50E+3nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (66 nM) using [14C]-AA (50 uM) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProstaglandin G/H synthase 1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 using whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article