BDBM22975 2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenoxyethyl)benzamide::CHEMBL148545::Meclofenamic acid derivative, 27

SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCOc2ccccc2)c1Cl

InChI Key InChIKey=CBUNQTSLJBKXPU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 22975   

TargetProstaglandin G/H synthase 2(Human)
Vanderbilt University School of Medicine

LigandPNGBDBM22975(CHEMBL148545 | 2-[(2,6-dichloro-3-methylphenyl)ami...)
Affinity DataIC50: 150nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22975(CHEMBL148545 | 2-[(2,6-dichloro-3-methylphenyl)ami...)
Affinity DataIC50: 150nMAssay Description:Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

LigandPNGBDBM22975(CHEMBL148545 | 2-[(2,6-dichloro-3-methylphenyl)ami...)
Affinity DataIC50: 400nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

LigandPNGBDBM22975(CHEMBL148545 | 2-[(2,6-dichloro-3-methylphenyl)ami...)
Affinity DataIC50: 400nMAssay Description:Inhibition of the wild type murine Prostaglandin G/H synthase 2 wild-type enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt University School of Medicine

LigandPNGBDBM22975(CHEMBL148545 | 2-[(2,6-dichloro-3-methylphenyl)ami...)
Affinity DataIC50: 550nMAssay Description:Inhibition of the Arg120Ala murine COX-2 mutant enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Vanderbilt University School of Medicine

LigandPNGBDBM22975(CHEMBL148545 | 2-[(2,6-dichloro-3-methylphenyl)ami...)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22975(CHEMBL148545 | 2-[(2,6-dichloro-3-methylphenyl)ami...)
Affinity DataIC50: 6.60E+4nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed