BDBM231231 US9346782, 11a::US9346782, 11b::US9346782, 11c

SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnnn1C

InChI Key InChIKey=KCEVZBCVYHCXBO-UHFFFAOYSA-N

Data  3 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 231231   

TargetNuclear receptor ROR-gamma [258-518](Artificial Sequence)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM231231(US9346782, 11b | US9346782, 11c | US9346782, 11a)
Affinity DataKd:  77nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [258-518](Artificial Sequence)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM231231(US9346782, 11b | US9346782, 11c | US9346782, 11a)
Affinity DataKd:  290nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [258-518](Artificial Sequence)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM231231(US9346782, 11b | US9346782, 11c | US9346782, 11a)
Affinity DataKd:  36nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [258-518,Y502F](Artificial Sequence)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM231231(US9346782, 11b | US9346782, 11c | US9346782, 11a)
Affinity DataIC50: 110nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [258-518,Y502F](Artificial Sequence)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM231231(US9346782, 11b | US9346782, 11c | US9346782, 11a)
Affinity DataIC50: 210nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [258-518,Y502F](Artificial Sequence)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM231231(US9346782, 11b | US9346782, 11c | US9346782, 11a)
Affinity DataIC50: 15nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent