BDBM2313 1,5-Diphenyl-3-methyl-4-propargylpyrazole::1,5-Diphenyl-3-methylpyrazole (DPP) analogue 22::3-methyl-1,5-diphenyl-4-(prop-2-yn-1-yl)-1H-pyrazole

SMILES Cc1nn(c(c1CC#C)-c1ccccc1)-c1ccccc1

InChI Key InChIKey=KXQUASMFJMJOEJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2313   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM2313(3-methyl-1,5-diphenyl-4-(prop-2-yn-1-yl)-1H-pyrazo...)
Affinity DataIC50: 1.34E+4nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,P823L]/[588-1147,P823L](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM2313(3-methyl-1,5-diphenyl-4-(prop-2-yn-1-yl)-1H-pyrazo...)
Affinity DataIC50: 1.54E+3nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2004
Entry Details Article
PubMed