BDBM23242 1,2(1,5)-Isoxazole, IOA1::3-hydroxy-1,2-oxazole-4-carboxylic acid

SMILES OC(=O)c1co[nH]c1=O

InChI Key InChIKey=JLPHBZYAQYOJND-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 23242   

TargetL-lactate dehydrogenase B chain(Human)
University of Bristol

LigandPNGBDBM23242(3-hydroxy-1,2-oxazole-4-carboxylic acid | 1,2(1,5)...)
Affinity DataIC50: 5.40E+4nMAssay Description:An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2008
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM23242(3-hydroxy-1,2-oxazole-4-carboxylic acid | 1,2(1,5)...)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetL-lactate dehydrogenase(Plasmodium falciparum)
University of Bristol

LigandPNGBDBM23242(3-hydroxy-1,2-oxazole-4-carboxylic acid | 1,2(1,5)...)
Affinity DataKi:  470nM ΔG°:  -8.63kcal/mole IC50: 1.10E+3nMpH: 7.5 T: 2°CAssay Description:An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2008
Entry Details Article
PubMed