BDBM23300 4-amino-7-chloroquinoline (ACQ)-based compound, 5::7-chloroquinolin-4-amine::CHEMBL44789

SMILES c1cc2c(ccnc2cc1Cl)N

InChI Key InChIKey=NDRZSRWMMUGOBP-UHFFFAOYSA-N

Data  4 IC50  1 Kd  2 EC50  1 Other

PDB links: 3 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 23300   

TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
National Cancer Institute At Frederick

LigandPNGBDBM23300(7-chloroquinolin-4-amine | CHEMBL44789 | 4-amino-7...)
Affinity DatapH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2008
Entry Details Article
PubMed
TargetHistidine-rich protein PFHRP-II(malaria parasite P. falciparum)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM23300(7-chloroquinolin-4-amine | CHEMBL44789 | 4-amino-7...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1/2(Human)
Roche Discovery Welwyn

Curated by ChEMBL
LigandPNGBDBM23300(7-chloroquinolin-4-amine | CHEMBL44789 | 4-amino-7...)
Affinity DataIC50: 1.68E+5nMAssay Description:Inhibitory activity against (IMPDH) inosine 5'-monophosphate dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2018
Entry Details Article
PubMed
TargetNuclear receptor subfamily 4 group A member 2(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM23300(7-chloroquinolin-4-amine | CHEMBL44789 | 4-amino-7...)
Affinity DataEC50:  2.59E+5nMAssay Description:Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 4 group A member 2(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM23300(7-chloroquinolin-4-amine | CHEMBL44789 | 4-amino-7...)
Affinity DataEC50:  2.59E+5nMAssay Description:Agonist activity at Nurr1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSon of sevenless homolog 2(Homo sapiens)
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM23300(7-chloroquinolin-4-amine | CHEMBL44789 | 4-amino-7...)
Affinity DataKd:  3.30E+5nMAssay Description:Binding affinity to biotinylated SOS2 (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFermitin family homolog 1(Homo sapiens)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM23300(7-chloroquinolin-4-amine | CHEMBL44789 | 4-amino-7...)
Affinity DataIC50: 2.50E+6nMAssay Description:Inhibition of His6-tagged KIND1 (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetFermitin family homolog 2(Homo sapiens)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM23300(7-chloroquinolin-4-amine | CHEMBL44789 | 4-amino-7...)
Affinity DataIC50: 2.50E+6nMAssay Description:Inhibition of His6-tagged KIND2 (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed