BDBM234352 9-Benzyl-2,3,4,7,8,9,10,12-octahydro-6H-pyrido[4′,3′:4,5]thieno[2,3-d]pyrimido[1,2-a]pyrimidin-6-one (10)

SMILES O=C1N2CCCN=C2Nc2sc3CN(Cc4ccccc4)CCc3c12

InChI Key InChIKey=HRUOTNAMMONHGE-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 234352   

TargetAcetylcholinesterase(Electric eel)
University of Bonn

LigandPNGBDBM234352(9-Benzyl-2,3,4,7,8,9,10,12-octahydro-6H-pyrido[4&#...)
Affinity DataKi:  2.07E+3nM ΔG°:  -7.75kcal/mole IC50: 1.51E+3nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bonn

LigandPNGBDBM234352(9-Benzyl-2,3,4,7,8,9,10,12-octahydro-6H-pyrido[4&#...)
Affinity DataIC50: 5.69E+3nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bonn

LigandPNGBDBM234352(9-Benzyl-2,3,4,7,8,9,10,12-octahydro-6H-pyrido[4&#...)
Affinity DataIC50: 5.15E+4nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed