BDBM234353 2,3,8,9,10,11-Hexahydro-benzothieno[3,2-e]imidazo[1,2-c]pyrimidine (11)

SMILES C1CN2C=Nc3sc4CCCCc4c3C2=N1

InChI Key InChIKey=IAMFUBHYGGVHLJ-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 234353   

TargetAcetylcholinesterase(Electric eel)
University of Bonn

LigandPNGBDBM234353(2,3,8,9,10,11-Hexahydro-benzothieno[3,2-e]imidazo[...)
Affinity DataKi:  1.32E+3nM ΔG°:  -8.02kcal/mole IC50: 1.75E+3nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bonn

LigandPNGBDBM234353(2,3,8,9,10,11-Hexahydro-benzothieno[3,2-e]imidazo[...)
Affinity DataIC50: 5.60E+4nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bonn

LigandPNGBDBM234353(2,3,8,9,10,11-Hexahydro-benzothieno[3,2-e]imidazo[...)
Affinity DataIC50: 8.80E+4nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed