BDBM234356 10-Benzyl-3,4,9,10,11,12-hexahydro-2H-pyrido[4′,3′:4,5]thieno[3,2-e]pyrimido[1,2-c]pyrimidin (14)

SMILES C(N1CCc2c(C1)sc1N=CN3CCCN=C3c21)c1ccccc1

InChI Key InChIKey=WYEPICZMXLIHIB-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 234356   

TargetAcetylcholinesterase(Electric eel)
University of Bonn

LigandPNGBDBM234356(10-Benzyl-3,4,9,10,11,12-hexahydro-2H-pyrido[4R...)
Affinity DataKi:  1.50E+3nM ΔG°:  -7.94kcal/mole IC50: 1.73E+3nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bonn

LigandPNGBDBM234356(10-Benzyl-3,4,9,10,11,12-hexahydro-2H-pyrido[4R...)
Affinity DataIC50: 6.25E+4nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bonn

LigandPNGBDBM234356(10-Benzyl-3,4,9,10,11,12-hexahydro-2H-pyrido[4R...)
Affinity DataIC50: 1.19E+5nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed