BDBM234973 US9556148, 44::n-(cyanomethyl)-4-(5-fluoro-2-((4-(4-morpholinopiperidin-1-yl)phenyl)amino)pyrimidin-4-yl)benzamide

SMILES Fc1cnc(Nc2ccc(cc2)N2CCC(CC2)N2CCOCC2)nc1-c1ccc(cc1)C(=O)NCC#N

InChI Key InChIKey=OJWUERASKIACOC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 234973   

TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234973(n-(cyanomethyl)-4-(5-fluoro-2-((4-(4-morpholinopip...)
Affinity DataIC50: 6.70nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234973(n-(cyanomethyl)-4-(5-fluoro-2-((4-(4-morpholinopip...)
Affinity DataIC50: 4.90nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234973(n-(cyanomethyl)-4-(5-fluoro-2-((4-(4-morpholinopip...)
Affinity DataIC50: 16.6nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234973(n-(cyanomethyl)-4-(5-fluoro-2-((4-(4-morpholinopip...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234973(n-(cyanomethyl)-4-(5-fluoro-2-((4-(4-morpholinopip...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234973(n-(cyanomethyl)-4-(5-fluoro-2-((4-(4-morpholinopip...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed