BDBM235642 (E)-1-(2,4-dihydroxyphenyl)-3-(2,3-dihydroxyphenyl)-2-propen-1-one (17)

SMILES Oc1ccc(C(=O)\C=C\c2cccc(O)c2O)c(O)c1

InChI Key InChIKey=IUKUGGBBLOTFNV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 235642   

TargetBeta-secretase 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

LigandPNGBDBM235642((E)-1-(2,4-dihydroxyphenyl)-3-(2,3-dihydroxyphenyl...)
Affinity DataIC50: 270nMpH: 4.5 T: 2°CAssay Description:The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

LigandPNGBDBM235642((E)-1-(2,4-dihydroxyphenyl)-3-(2,3-dihydroxyphenyl...)
Affinity DataIC50: 270nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetIntegrase(Human immunodeficiency virus type 1)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM235642((E)-1-(2,4-dihydroxyphenyl)-3-(2,3-dihydroxyphenyl...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of HIV1 His6-tagged integrase-human GST tagged LEDGF/p75 (373-442 residues) interaction after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed