BDBM23721 4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl-1H-pyrazole::N-Benzoylpyrazole deriv., 29

SMILES Cc1nn(C(=O)c2ccccc2F)c(C)c1Cl

InChI Key InChIKey=LGPJDOCFLPQZPI-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23721   

TargetChymotrypsin-C(Human)
Montana State University

LigandPNGBDBM23721(4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50: 3.50E+3nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
Montana State University

LigandPNGBDBM23721(4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Montana State University

LigandPNGBDBM23721(4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Montana State University

LigandPNGBDBM23721(4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
Montana State University

LigandPNGBDBM23721(4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetCathepsin D(Human)
Montana State University

LigandPNGBDBM23721(4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Montana State University

LigandPNGBDBM23721(4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataKi:  9.00E+3nM ΔG°:  -6.88kcal/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed