BDBM240232 US9403843, E64

SMILES CC(C)C[C@H](NC(=O)C1O[C@@H]1C(O)=O)C(=O)NCCCCNC(N)=N

InChI Key InChIKey=LTLYEAJONXGNFG-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 240232   

TargetCalpain-1 catalytic subunit(Human)
Columbia University

US Patent
LigandPNGBDBM240232(US9403843, E64)
Affinity DataIC50: 100nMpH: 7.4Assay Description:The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetCalpain-1 catalytic subunit(Pig)
Columbia University

US Patent
LigandPNGBDBM240232(US9403843, E64)
Affinity DataKi:  4.00E+3nM ΔG°:  -7.48kcal/molepH: 7.6 T: 2°CAssay Description:Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent