BDBM243372 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-methoxy-2-ethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)pyrimidine-2,4-diamine::US10053458, 4

SMILES CCN1CCc2cc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)c(OC)cc2C1

InChI Key InChIKey=ZIIGGCHAZOMSOL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 243372   

TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM243372(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-me...)
Affinity DataIC50: 3nMAssay Description:Inhibition of ALK (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor [L1196M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM243372(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-me...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
US Patent

TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM243372(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-me...)
Affinity DataIC50: 10nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
US Patent

TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM243372(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-me...)
Affinity DataIC50: 20nMAssay Description:Inhibition of crizotinib-resistant ALK L1196M mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed