BDBM24395 3,4-dihydro-2-quinolone (DHQ) derivative, 34::5-chloro-N-{1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl}-1H-indole-2-carboxamide

SMILES OC[C@H](O)CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(Cl)ccc2[nH]1

InChI Key InChIKey=BANRVMJUSXDIBF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24395   

TargetGlycogen phosphorylase, liver form(Human)
Astrazeneca

LigandPNGBDBM24395(5-chloro-N-{1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2...)
Affinity DataIC50: 44nMAssay Description:The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2008
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM24395(5-chloro-N-{1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2...)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed