BDBM244127 US9428492, 6::US9428492, 6a::US9428492, 6b

SMILES Cc1nc(C(O)C2CC2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C

InChI Key InChIKey=KBFMDGZXCNZBCY-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 244127   

LigandPNGBDBM244127(US9428492, 6a | US9428492, 6b | US9428492, 6)
Affinity DataKi:  0.170nM ΔG°:  -13.3kcal/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent

LigandPNGBDBM244127(US9428492, 6a | US9428492, 6b | US9428492, 6)
Affinity DataKi:  0.360nM ΔG°:  -12.9kcal/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent

LigandPNGBDBM244127(US9428492, 6a | US9428492, 6b | US9428492, 6)
Affinity DataKi:  2.60nM ΔG°:  -11.7kcal/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM244127(US9428492, 6a | US9428492, 6b | US9428492, 6)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition assay using CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent