BDBM244149 US9428492, 19::US9428492, 19a

SMILES CCC(O)c1nc(C)nn1-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C

InChI Key InChIKey=QLHCGKWHKVNLHB-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 244149   

LigandPNGBDBM244149(US9428492, 19a | US9428492, 19)
Affinity DataKi:  0.550nM ΔG°:  -12.6kcal/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent

LigandPNGBDBM244149(US9428492, 19a | US9428492, 19)
Affinity DataKi:  1.30nM ΔG°:  -12.1kcal/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM244149(US9428492, 19a | US9428492, 19)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition assay using CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent