BDBM24469 4-({6-phenyl-[1,2,4]triazolo[3,4-a]pyridin-3-yl}methyl)phenol::4-[(6-phenyl[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl]phenol::Triazolopyridine, 3c::US9066954, 66

SMILES Oc1ccc(Cc2nnc3ccc(cn23)-c2ccccc2)cc1

InChI Key InChIKey=AIZTYZRNBCCRMR-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 24469   

TargetHepatocyte growth factor receptor(Human)
Amgen

US Patent
LigandPNGBDBM24469(4-[(6-phenyl[1,2,4]triazolo[4,3-a]pyridin-3-yl)met...)
Affinity DataKi:  1.23E+3nM ΔG°:  -8.11kcal/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Amgen

US Patent
LigandPNGBDBM24469(4-[(6-phenyl[1,2,4]triazolo[4,3-a]pyridin-3-yl)met...)
Affinity DataIC50: 2.10E+3nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2008
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

US Patent
LigandPNGBDBM24469(4-[(6-phenyl[1,2,4]triazolo[4,3-a]pyridin-3-yl)met...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

US Patent
LigandPNGBDBM24469(4-[(6-phenyl[1,2,4]triazolo[4,3-a]pyridin-3-yl)met...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed