BDBM245009 US9422293, 246::US9422293, 276::US9422293, 277::US9738649, Example 276

SMILES CC1CCCCN1c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F

InChI Key InChIKey=MHECYLUEHNFZEI-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 245009   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 3nMT: 2°CAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 10nMT: 2°CAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 20nMT: 2°CAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 50nMT: 2°CAssay Description:The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 40nMT: 2°CAssay Description:The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 50nMT: 2°CAssay Description:The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 3nMAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 50nMAssay Description:The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 10nMAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 40nMAssay Description:The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 20nMAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

LigandPNGBDBM245009(US9422293, 277 | US9422293, 276 | US9422293, 246 |...)
Affinity DataIC50: 50nMAssay Description:The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent