BDBM246599 DNA topoisomerase inhibitor, 1

SMILES Cc1nc[nH]c1C(=O)NNC(=S)NC(=O)c1ccccc1

InChI Key InChIKey=BWMKVHIEABIUQS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 246599   

TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM246599(DNA topoisomerase inhibitor, 1)
Affinity DataIC50: 1.00E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM246599(DNA topoisomerase inhibitor, 1)
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed