BDBM247150 (S,E)-2-Methyl-N-(2,2,2-trifluoro-1-(4-((5,5,5-trifluoropentyl)oxy phenyl)ethylidene)propane-2-sulfinamide::US9701672, 4::US9701672, 54

SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccc(s2)C2CC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F

InChI Key InChIKey=OCIJLERLWKVYMC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 247150   

LigandPNGBDBM247150(US9701672, 4 | (S,E)-2-Methyl-N-(2,2,2-trifluoro-1...)
Affinity DataIC50: 0.900nMpH: 7.4Assay Description:The MGAT enzyme reactions were performed in Corning FALCON 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

LigandPNGBDBM247150(US9701672, 4 | (S,E)-2-Methyl-N-(2,2,2-trifluoro-1...)
Affinity DataIC50: 1.10nMpH: 7.4Assay Description:The MGAT enzyme reactions were performed in Corning FALCON 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

LigandPNGBDBM247150(US9701672, 4 | (S,E)-2-Methyl-N-(2,2,2-trifluoro-1...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human MGAT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM247150(US9701672, 4 | (S,E)-2-Methyl-N-(2,2,2-trifluoro-1...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of human MGAT2 using 2-oleoylglycerol and oleoyl-coenzyme A as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM247150(US9701672, 4 | (S,E)-2-Methyl-N-(2,2,2-trifluoro-1...)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of mouse MGAT2 using 2-oleoylglycerol and oleoyl-coenzyme A as substrate by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed