BDBM247370 US9447092, 3

SMILES Cc1nc(CN2CCN(CC2)c2c(Cl)cnc3[nH]c(nc23)-c2cn(C)nc2C)no1

InChI Key InChIKey=ZYQKMYRXVHUATB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 247370   

TargetCytochrome P450 3A4(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetAurora kinase A(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 52nMAssay Description:Myc-tagged Aurora A was transfected in Hela cells using Lipofectamine LTX in 24 well plates, and 24 hours after transfection, cells were treated with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 9.50E+3nMAssay Description:All hERG percentage inhibitions at 10 uM compound concentration were determined by Millipore in a high-throughput cell-based electrophysiology assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetCytochrome P450 1A2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2A6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent