BDBM24762 N-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)(phenyl)methyl]-3-(methylsulfanyl)propanamide::pyrimidone, 40

SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(NC(=O)CCSC)c4ccccc4)n(C)c3=O)c2cc1OC

InChI Key InChIKey=UGUJTUUACHEEGS-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24762   

LigandPNGBDBM24762(N-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...)
Affinity DataKi:  52nM ΔG°:  -9.83kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2008
Entry Details Article
PubMed
LigandPNGBDBM24762(N-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...)
Affinity DataIC50: 52nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed