BDBM249278 US10017501, Compound 1020-19::US9458145, 1020-19

SMILES Cc1noc(C)c1-c1cc(-c2cccnc2-c2ccccc2)c2nc([nH]c2c1)C1CC1

InChI Key InChIKey=ZTTDZAWIKNDGPB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249278   

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249278(US9458145, 1020-19 | US10017501, Compound 1020-19)
Affinity DataIC50: 28nMpH: 7.5 T: 2°CAssay Description:Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249278(US9458145, 1020-19 | US10017501, Compound 1020-19)
Affinity DataIC50: 134nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249278(US9458145, 1020-19 | US10017501, Compound 1020-19)
Affinity DataIC50: 134nMpH: 7.5 T: 2°CAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249278(US9458145, 1020-19 | US10017501, Compound 1020-19)
Affinity DataIC50: 172nMpH: 7.5 T: 2°CAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249278(US9458145, 1020-19 | US10017501, Compound 1020-19)
Affinity DataIC50: 172nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent